Soluble transforming growth factor beta-1 enhances murine mast cell release of Interleukin 6 in IgE-independent and Interleukin 13 in IgE-dependent settings in vitro.

David O Lyons Michele R PlewesNicholas A Pullen

Published in: PloS one (2018)

These data reveal a novel positive effect of soluble TGF-β1 on mast cell activation in vitro, suggesting mast cells may be activated through a non-canonical pathway by TGF-β1. Understanding this interaction will provide insight into the potential role of mast cells in settings where TGF-β1 is produced in an aberrant manner, such as in and around high grade tumors.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
high grade
low grade
electronic health record
single cell
big data
machine learning
human health
risk assessment
data analysis