Palladium-Catalyzed Regioselective Synthesis of 2-SF 5 -Indenols and Further Derivatizations.

A palladium-catalyzed synthesis of 2-SF 5 -indenols has been developed by reacting commercially available boronic acid derivatives and readily accessible SF 5 -alkynes. The present methodology is fully regioselective thanks to the intrinsic polarization of SF 5 -alkynes. A selection of downstream functionalizations has been performed to highlight the versatility of 2-SF 5 -indenols and indenones as platforms for the design of more complex SF 5 -containing molecules.