Protection of Hearing Loss in Ototoxic Mouse Model Through SPIONs and Dexamethasone-Loaded PLGA Nanoparticle Delivery by Magnetic Attraction.

Jeong-Eun ParkWoo Cheol KimSung Kyun KimYeji AhnSun Mok HaGahee KimSeonmin ChoiWan Su YunTae-Hoon KongSu Hoon LeeDong Jun ParkJin Sil ChoiJaehong Key Young Joon Seo

Published in: International journal of nanomedicine (2022)

Our findings suggest that SPIONs with Dexa and magnetic field application prevent the progression of ototoxicity-induced hearing loss through anti-apoptotic mechanisms in the inner ear.

Keyphrases

hearing loss
mouse model
drug delivery
cell death
high glucose
diabetic rats
low dose
cancer therapy
high dose
anti inflammatory
drug release
endothelial cells
high resolution
bone regeneration
mass spectrometry
iron oxide
simultaneous determination
tandem mass spectrometry
liquid chromatography