Genotoxic Repercussion of High-Intensity Radiation (X-Rays) on Hospital Radiographers.
Haripriya Kuchi BhotlaBalamuralikrishnan BalasubramanianKannan R R RengasamyVijaya Anand ArumugamKarthick Kumar AlagamuthuChithravel VadivalaganAditi ChaudharyAmer M AlanaziManikantan PappuswamyArun MeyyazhaganPublished in: Environmental and molecular mutagenesis (2022)
Recent technological advances in the medical field have increased the plausibility of exposing humans to high-intensity wavelength radiations like X-rays and gamma rays while diagnosing or treating specific medical maladies. These radiations induce nucleotide changes and chromosomal alterations in the exposed population, intentionally or accidentally. A radiological investigation is regularly used in identifying the disease, especially by the technicians working in intensive care units. The current study observes the genetic damages like chromosomal abnormalities (CA) in clinicians who are occupationally exposed to high-intensity radiations (X-rays) at their workplaces using universal cytogenetic tools like micronucleus assay (MN), sister chromatid exchange and comet assay. The study was conducted between 100 exposed practitioners from the abdominal scanning, chest scanning, cranial and orthopedic or bone scanning department and age-matched healthy controls. We observed a slightly higher rate of MN and CA (P<0.05) in orthopedic and chest department practitioners than in other departments concerning increasing age and duration of exposure at work. Our results emphasize taking extra precautionary measures in clinical and hospital radiation laboratories to protect the practitioners. This article is protected by copyright. All rights reserved.
Keyphrases
- high intensity
- resistance training
- healthcare
- primary care
- high resolution
- intensive care unit
- copy number
- general practice
- palliative care
- genome wide
- gene expression
- bone mineral density
- mass spectrometry
- dna methylation
- body composition
- postmenopausal women
- adverse drug
- acute respiratory distress syndrome
- transition metal