Inflammatory Response: A Crucial Way for Gut Microbes to Regulate Cardiovascular Diseases.
Wen WangLuo-Jiang ZhuYue-Qi LengYu-Wan WangTe ShiWei-Zhong WangJia-Cen SunPublished in: Nutrients (2023)
Gut microbiota is the largest and most complex microflora in the human body, which plays a crucial role in human health and disease. Over the past 20 years, the bidirectional communication between gut microbiota and extra-intestinal organs has been extensively studied. A better comprehension of the alternative mechanisms for physiological and pathophysiological processes could pave the way for health. Cardiovascular disease (CVD) is one of the most common diseases that seriously threatens human health. Although previous studies have shown that cardiovascular diseases, such as heart failure, hypertension, and coronary atherosclerosis, are closely related to gut microbiota, limited understanding of the complex pathogenesis leads to poor effectiveness of clinical treatment. Dysregulation of inflammation always accounts for the damaged gastrointestinal function and deranged interaction with the cardiovascular system. This review focuses on the characteristics of gut microbiota in CVD and the significance of inflammation regulation during the whole process. In addition, strategies to prevent and treat CVD through proper regulation of gut microbiota and its metabolites are also discussed.
Keyphrases
- human health
- cardiovascular disease
- risk assessment
- inflammatory response
- heart failure
- climate change
- oxidative stress
- endothelial cells
- healthcare
- systematic review
- blood pressure
- cardiovascular risk factors
- cardiovascular events
- public health
- type diabetes
- mental health
- toll like receptor
- metabolic syndrome
- lps induced
- multidrug resistant
- drug induced
- cardiac resynchronization therapy
- transcatheter aortic valve replacement