Seasonality, Clinical Characteristics, and Outcomes of Respiratory Syncytial Virus Disease by Subtype Among Children Aged <5 Years: New Vaccine Surveillance Network, United States, 2016-2020.
Ariana P ToepferJustin Z AmarinAndrew J SpiekerLaura S StewartMary Allen StaatElizabeth P SchlaudeckerGeoffrey A WeinbergPeter G SzilagyiJanet A EnglundEileen J KleinMarian G MichaelsJohn V WilliamsRangaraj SelvaranganChristopher J HarrisonJoana Y LivelyPedro A PiedraVasanthi AvadhanulaBrian RhaJames ChappellMeredith L McMorrowHeidi MolineNatasha B HalasaPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Findings indicate that RSV-A and RSV-B may only be marginally clinically distinguishable, but both subtypes are associated with medically attended illness in children aged <5 years. Furthermore, circulation of RSV subtypes varies substantially each year, seasonally and geographically. With introduction of new RSV prevention products, this highlights the importance of continued monitoring of RSV-A and RSV-B subtypes.