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Establishment of a framework for assessing mortality in persons with congenital hemophilia A and its application to an adverse event reporting database.

Steven W PipeRebecca Kruse-JarresJohnny N MahlanguGlenn F PierceFlora PeyvandiPeter KueblerChristian De FordFabián SanabriaRichard H KoTiffany ChangCharles R M Hay
Published in: Journal of thrombosis and haemostasis : JTH (2021)
A conceptual framework for examining mortality in PwcHA receiving any hemophilia therapy is proposed to analyze and interpret fatalities, enabling consistent and objective assessment. Application of the framework using FAERS data suggests a generally consistent pattern of reported mortality across HA treatments, supporting the utility of this unified approach.
Keyphrases
  • cardiovascular events
  • risk factors
  • adverse drug
  • electronic health record
  • machine learning
  • coronary artery disease
  • bone marrow
  • cell therapy
  • replacement therapy