Glucose-Regulated Protein 94 Modulates the Response of Osteosarcoma to Chemotherapy.

Chien-Yu HuangPo-Li WeiJin-Wun WangPrecious Takondwa MakondiMing-Te HuangHsin-An Chen Yu-Jia Chang

Published in: Disease markers (2019)

Therefore, GRP94 silencing may increase the resistance of MG63 and 143B cells to paclitaxel, gemcitabine, and epirubicin treatments by inhibiting the induction of apoptosis. Thus, GRP94 may be a key biomarker for the chemotherapeutic response of OS.

Keyphrases

endoplasmic reticulum stress
locally advanced
oxidative stress
signaling pathway
cell death
type diabetes
metabolic syndrome
skeletal muscle
adipose tissue
cell cycle arrest
binding protein
protein protein
rectal cancer
small molecule