Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death.

Jarrod John SandowGiuseppe InfusiniAliaksei Z HolikGabriela BrumattiTessa V AverinkPaul G EkertAndrew I Webb

Published in: Proteomics. Clinical applications (2017)

These discoveries highlight how this new class of drugs affects AML cell biology and cell survival, and may help identify novel targets and strategies to increase treatment efficacy.

Keyphrases

cell death
acute myeloid leukemia
single cell
long non coding rna
stem cells
long noncoding rna
combination therapy
signaling pathway
bone marrow
replacement therapy