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Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses.

Mamdooh H GhoneumMohamed S A El-Gerbed
Published in: Cancer chemotherapy and pharmacology (2021)
HPE has the ability to ameliorate methotrexate-induced liver injury in rats by mechanisms that include boosting antioxidative responses and down-regulating MDA and pro-inflammatory cytokine production.
Keyphrases
  • anti inflammatory
  • high glucose
  • endothelial cells
  • drug induced
  • diabetic rats
  • high dose
  • oxidative stress
  • low dose
  • cell proliferation
  • signaling pathway