The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices.

Maria A MeierClement E LemercierChristoph KulischBéla KissBalázs LendvaiNika AdhamZoltan Gerevich

Published in: British journal of pharmacology (2020)

Data from this study indicate that cariprazine stabilizes pathological hippocampal gamma oscillations, presumably by its partial agonistic profile. The results demonstrate in vitro gamma oscillations as predictive biomarkers to study the effects of antipsychotics preclinically at the network level.

Keyphrases

working memory
oxidative stress
electronic health record
blood brain barrier
cerebral ischemia
temporal lobe epilepsy
data analysis