Interaction of genetic risk and lifestyle on the incidence of atrial fibrillation.

Tanja Charlotte FrederiksenMorten Krogh ChristiansenEmelia J BenjaminKim OvervadAnja OlsenMette K AndersenTorben HansenNiels GrarupHenrik Kjaerulf JensenChristina C Dahm

Published in: Heart (British Cardiac Society) (2023)

The rates of AF increased gradually with worse lifestyle within each category of genetic risk. We found a positive interaction on an additive scale between genetic risk and lifestyle, suggesting that risk factor modification is especially important in individuals with a high genetic risk of AF.

Keyphrases

atrial fibrillation
genome wide
metabolic syndrome
risk factors
physical activity
cardiovascular disease
copy number
heart failure
percutaneous coronary intervention
left ventricular
mitral valve
direct oral anticoagulants