Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes.

Karel SoučekAlice MalenovskáZuzana KahounováJán RemšíkZuzana HolubcováTomáš SoukupDaniela KurfürstováJan BouchalTereza SuchánkováEva SlabákováAleš Hampl

Published in: Journal of assisted reproduction and genetics (2018)

To the best of our knowledge, this is the first documentation of cytokine GDF-15 presence in follicular fluid. Its concentration was not associated with donor/patient fertility status. Our data also show that GDF-15 is expressed and inducible in both normal healthy and cancerous granulosa cells, as well as in oocytes.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
electronic health record
endoplasmic reticulum stress
case report
cell death
cell proliferation
adipose tissue
metabolic syndrome
deep learning
induced pluripotent stem cells
data analysis
advance care planning