Non-vitamin K antagonist oral anticoagulants, proton pump inhibitors and gastrointestinal bleeds.

Joris J KomenAnton PottegårdPaul HjemdahlAukje K Mantel-TeeuwisseBjörn WettermarkMaja HellfritzschJ HallasRon HeringsLisa SmitsThomas ForslundOlaf Klungel

Published in: Heart (British Cardiac Society) (2021)

Concomitant treatment with a PPI in NOAC-treated patients with AF is associated with a reduced risk of severe UGIB. This indicates that PPI cotreatment can be considered, in particular among the elderly patients, patients with a HAS-BLED score ≥3, and/or in patients on concomitant antiplatelet therapy.

Keyphrases

antiplatelet therapy
oral anticoagulants
atrial fibrillation
end stage renal disease
acute coronary syndrome
percutaneous coronary intervention
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
protein protein
early onset
patient reported outcomes
replacement therapy
drug induced