Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles.

Cory D SagoBrandon R KrupczakMelissa P LokugamageZubao GanJames E Dahlman

Published in: Cellular and molecular bioengineering (2019)

These data suggest subsets of liver microenvironmental cells can differentially interact with nanoparticles in vivo, thereby altering LNP delivery. More generally, the data suggest that nucleic acid biodistribution is not sufficient to predict functional nucleic acid delivery in vivo.

Keyphrases

nucleic acid
electronic health record
induced apoptosis
big data
stem cells
single cell
cell therapy
peripheral blood
data analysis
signaling pathway
oxidative stress
mesenchymal stem cells
walled carbon nanotubes