Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour.
Jadranka ŠanjugKrunoslav KunaMarina Šprem GoldštajnLidija Fumić DunkićAndreja CarekDubravka Negovetić VranićPublished in: Journal of clinical medicine (2023)
The COMT gene polymorphism was associated with pain perception and anxiety among parturients. The COMT gene polymorphism GA was associated with negative pain perception among labouring women. Nitrous oxide showed statistical significance in anxiolytic efficacy during labour in women with mild anxiety as a personality trait. Anxiolytic efficacy of nitrous oxide has shown better efficacy in parturients with the COMT gene polymorphism AA.