Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses.
Harold A SilvermanAisling TynanTyler D HeplerEric H ChangManojkumar GunasekaranJian Hua LiTomás S HuertaTea TsaavaQing ChangMeghan E AddorisioAdrian C ChenDane A ThompsonValentin A PavlovMichael BrinesKevin J TraceySangeeta S ChavanPublished in: Molecular medicine (Cambridge, Mass.) (2023)
Thus, IL-1β activates TRPA1 vagus nerve signaling in the afferent arm of a reflex anti-inflammatory response which inhibits cytokine release, induces hypothermia, and reduces the mortality of infection. This discovery establishes that TRPA1, an ion channel known previously as a pro-inflammatory detector of cold, pain, itch, and a wide variety of noxious molecules, also plays a specific anti-inflammatory role via activating reflex anti-inflammatory activity.
Keyphrases
- inflammatory response
- cardiac arrest
- anti inflammatory
- brain injury
- chronic pain
- peripheral nerve
- high glucose
- small molecule
- signaling pathway
- pain management
- lipopolysaccharide induced
- cardiovascular events
- neuropathic pain
- high throughput
- computed tomography
- magnetic resonance imaging
- drug induced
- spinal cord injury
- oxidative stress
- spinal cord
- cardiovascular disease
- binding protein
- blood brain barrier
- image quality
- wild type