A screen-printed electrode modified with tungsten disulfide nanosheets for nanomolar detection of the arsenic drug roxarsone.
Mani GovindasamySea-Fue WangR JothiramalingamS Noora IbrahimHamad A Al-LohedanPublished in: Mikrochimica acta (2019)
A sensitive electrochemical (voltammetric; DPV) sensor has been developed for the determination of coccidiostat drug (roxarsone) based on the use of an SPCE (screen-printed carbon electrode) modified with tungsten disulfide nanosheets (WS2 NSs). The electrochemical detection of roxarsone on the WS2-modified SPCE was examined by electrochemical strategies. XPS, XRD, Raman, SEM, TEM, EDS and EIS were used to characterize the nanosheets. The effects of scan rate, pH values (phosphate buffer) and buffer concentration were optimized. A selective roxarsone sensor was developed that works best at -0.64 V (vs. Ag/AgCl) and performs much better than the bare SPCE. Features include (a) a wider linear range (0.05 to 490 μM), (b) a nanomolar detection limit (0.03 μM) and (c) high sensitivity (29 μA·μM-1·cm-2). The modified SPCEs have been successfully applied to the determination of roxarsone in spiked meat samples where they gave high accuracy and good recoveries. Graphical abstract Synthesis of WS2 nanosheets and electrochemical detection of roxarsone.
Keyphrases
- label free
- molecularly imprinted
- reduced graphene oxide
- gold nanoparticles
- quantum dots
- loop mediated isothermal amplification
- highly efficient
- real time pcr
- ionic liquid
- metal organic framework
- computed tomography
- high throughput
- visible light
- emergency department
- magnetic resonance imaging
- drinking water
- risk assessment
- adverse drug
- high resolution
- low cost
- raman spectroscopy