Met-RANTES preserves the blood-brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice.

Jun YanWeilin XuCameron LenahanLei HuangUmut OcakJing WenGaigai LiWei HeChensheng LeJohn H ZhangLigen MoJiping Tang

Published in: Fluids and barriers of the CNS (2022)

Our findings demonstrate that CCR5 inhibition by Met-R improves neurological deficits after ICH by preserving BBB integrity through inhibiting CCR1/SRC/Rac1 signaling pathway in mice. Thus, Met-R has therapeutic potential in the management of ICH patients.

Keyphrases

tyrosine kinase
signaling pathway
dendritic cells
end stage renal disease
regulatory t cells
chronic kidney disease
ejection fraction
high fat diet induced
newly diagnosed
pi k akt
traumatic brain injury
blood brain barrier
epithelial mesenchymal transition
brain injury
type diabetes
subarachnoid hemorrhage