Serpentine supravenous hyperpigmentation related to carboplatin and vinorelbine chemotherapy: A case report.
Fatma Tunçez AkyürekNihal SariCeyhan UgurluogluGülcan Saylam KurtipekPublished in: Dermatologic therapy (2019)
Serpentine supravenous hyperpigmentation (SSH) is a unique type of chemotherapy-associated drug eruption, characterized by hyperpigmentation along the superficial venous network. Histopathology reveals an increase in melanin production without destruction of basal cells of the epidermis or dermal inflammatory infiltrate. Herein, we describe a patient who developed SSH after repeated intravenous infusions with carboplatin and vinorelbine; two medications that have been uncommonly reported in association with SSH previously.
Keyphrases
- phase ii study
- locally advanced
- rectal cancer
- induced apoptosis
- squamous cell carcinoma
- radiation therapy
- open label
- cell cycle arrest
- oxidative stress
- case report
- high dose
- endoplasmic reticulum stress
- emergency department
- clinical trial
- placebo controlled
- signaling pathway
- drug induced
- wound healing
- double blind
- pi k akt
- network analysis