The Few yet Fab p4 ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs.

Cancer-associated fibroblast (CAF) pro- and anti-pancreatic cancer functional dichotomy has been at the center of numerous studies. In this issue of Cancer Discovery , Helms and colleagues demonstrate that although pancreatic stellate cell-derived CAFs constitute a desmoplastic cell minority, these cells play a protumorigenic role via microenvironmental mechanomodulation. See related article by Helms et al., p. 484 .