Sucrose-Responsive Intercommunicated Janus Nanoparticles Network.
Sandra Jimenez-FalcaoDaniel TorresPaloma Martínez-RuizDiana VilelaRamón Martínez-MáñezReynaldo VillalongaPublished in: Nanomaterials (Basel, Switzerland) (2021)
Inspired by biological systems, the development of artificial nanoscale materials that communicate over a short distance is still at its early stages. This work shows a new example of a cooperating system with intercommunicated devices at the nanoscale. The system is based on the new sucrose-responsive Janus gold-mesoporous silica (Janus Au-MS) nanoparticles network with two enzyme-powered nanodevices. These nanodevices involve two enzymatic processes based on invertase and glucose oxidase, which are anchored on the Au surfaces of different Janus Au-MS nanoparticles, and N-acetyl-L-cysteine and [Ru(bpy)3]2+ loaded as chemical messengers, respectively. Sucrose acts as the INPUT, triggering the sequential delivery of two different cargoes through the enzymatic control. Nanoscale communication using abiotic nanodevices is a developing potential research field and may prompt several applications in different disciplines, such as nanomedicine.
Keyphrases
- cancer therapy
- sensitive detection
- atomic force microscopy
- mass spectrometry
- multiple sclerosis
- ms ms
- reduced graphene oxide
- hydrogen peroxide
- drug delivery
- staphylococcus aureus
- type diabetes
- blood glucose
- blood pressure
- gold nanoparticles
- nitric oxide
- quantum dots
- adipose tissue
- transcription factor
- living cells
- insulin resistance