Combined swimming with melatonin protects against behavioural deficit in cerebral ischemia-reperfusion injury induced rats associated with modulation of Mst1- MAPK -ERK signalling pathway.

Samah Mahmoud AbdelaalMarwa Mohamed Abdel RahmanLamiaa Mohamed MahmoudLaila Ahmed RashedTarek Ibrahim Abd El-GalilManal Moustafa Mahmoud

Published in: Archives of physiology and biochemistry (2024)

The protective contribution of combined strategy is associated with modulation in Macrophage-stimulating 1/mitogen-activated protein kinase/extracellular signal-regulated kinase (MST1/MAPK/ERK) pathway which may explain, at least in part, its protective potential.

Keyphrases

signaling pathway
pi k akt
ischemia reperfusion injury
oxidative stress
cell proliferation
protein kinase
diabetic rats
tyrosine kinase
high glucose
adipose tissue
transcription factor
drug induced
endothelial cells
risk assessment
brain injury
cerebral ischemia