Investigating the impact of hypertension with and without diabetes on Alzheimer's disease risk: A clinico-pathological study.

Myuri RuthirakuhanWalter SwardfagerLisa XiongBradley J MacIntoshJennifer S RabinKrista L LanctôtJulie OttoyJoel RamirezJulia KeithSandra E Black

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

AD risk was studied in hypertensive (HTN+) individuals with/without diabetes (DM+/-). HTN+/DM+ and HTN+/DM- both had an increased risk of AD compared to HTN-/DM-. Post mortem analysis identified neuropathological differences between HTN+/DM+ and HTN+/DM-. In HTN+/DM+, AD risk was greater in those with AD neuropathology and CAA. In HTN+/DM-, AD risk was greater in those with cerebrovascular neuropathology.

Keyphrases

glycemic control
type diabetes
blood pressure
cardiovascular disease
metabolic syndrome
adipose tissue
mild cognitive impairment