The Adaptive Immune Landscape of the Colorectal Adenoma-Carcinoma Sequence.
João Augusto FreitasIrene GulloDiogo GarciaSara MirandaLouisa SpaansLídia PinhoJoana Pereira ReisFabiana SousaManuela BaptistaCarlos ResendeDina LeitãoCecília DurãesJosé Luís CostaFátima CarneiroJosé Carlos MachadoPublished in: International journal of molecular sciences (2021)
The colorectal ACS is characterized by a progressive loss of adaptive immune infiltrate and by the establishment of a progressively immune cold microenvironment. These changes do not appear to be related with the loss of immunogenicity of tumor cells, or to the onset of an immunosuppressive tumor microenvironment.