Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.
Denis SeyresAlessandra CabassiJohn J LambourneFrances BurdenSamantha FarrowHarriet McKinneyJoana BatistaCarly KempsterMaik PietznerOliver SlingsbyThong Huy CaoPaulene A QuinnLuca StefanucciMatthew C SimsKarola RehnstromClaire L AdamsAmy FraryBekir ErgüenerRoman KreuzhuberGabriele MocciaroSimona D'AmoreAlbert KoulmanLuigi GrassiJulian L GriffinLeong Loke NgAdrian ParkDavid B SavageClaudia LangenbergChristoph BockKate DownesNicholas J WarehamMichael AllisonMichele VaccaPaul D W KirkMattia FrontiniPublished in: Clinical epigenetics (2022)
We showed that the morbidly obese and lipodystrophy groups, despite some differences, shared a common cardiometabolic syndrome signature. We also showed that this could be used to discriminate, amongst the normal population, those individuals with a higher likelihood of presenting with the disease, even when not displaying the classic features.