Steroid Sulfatase Stimulates Intracrine Androgen Synthesis and is a Therapeutic Target for Advanced Prostate Cancer.

Cameron M ArmstrongChengfei LiuLiangren LiuJoy C YangWei LouRuining ZhaoShu NingAlan P LombardJinge ZhaoLeandro S D'AbronzoChristopher P EvansPui-Kai LiAllen C Gao

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These studies suggest that STS drives intracrine androgen synthesis and prostate cancer proliferation. Targeting STS represents a therapeutic strategy to treat CRPC and improve second-generation antiandrogen therapy.

Keyphrases

prostate cancer
radical prostatectomy
signaling pathway
cancer therapy
stem cells
drug delivery