Turning end-joining upside down in mitosis.

Marta Llorens-Agost Michael EnsmingerHang Phuong LeWolf-Dietrich Heyer Markus Löbrich

Published in: Molecular & cellular oncology (2021)

How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis.

Keyphrases

dna repair
circulating tumor
induced apoptosis
cell free
single molecule
dna damage
cell cycle arrest
signaling pathway
oxidative stress
cell proliferation
nucleic acid
cell death
structural basis