In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration.

Alison Jane CantyJohanna Sara JacksonLieven HuangAntonio TrabalzaCher BassGraham LittleMaria TortoraShabana KhanVincenzo De Paola

Published in: BMC biology (2020)

Our data illustrate how in vivo time-lapse imaging can provide new insights into the spatiotemporal dynamics and synaptic mechanisms of axon loss and assess therapeutic interventions in the injured mammalian brain.

Keyphrases

high resolution
physical activity
electronic health record
white matter
big data
mass spectrometry
blood brain barrier
artificial intelligence