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Circulating adult stem and progenitor cell numbers-can results be trusted?

Julia Maria KröpflMichelle SchmidYvonne Di MarzioKarine SchreiberChristina M Spengler
Published in: Stem cell research & therapy (2019)
Investigated MNC counts (LYM/MONO ratio) after cell isolation and staining did not always mimic WB conditions. Thus, final CPC results should be corrected accordingly, especially when reporting live CPC concentrations after DGC; otherwise, the CPC regenerative potential in circulation could be biased. This is of high importance in the context of non-invasively induced CPC mobilization such as by acute physical exercise, since these cell changes are small and conclusions drawn from published results might affect further applications of physical exercise as non-invasive therapy.
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