Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients.
Mai S KorkorTarek El-DesokyYoussef M MosaadDoaa M SalahAyman HammadPublished in: Italian journal of pediatrics (2023)
The C allele, CC and CT genotypes of Multidrug resistant 1 gene (C3435T) and the T allele, GT and TT genotypes of Multidrug resistant 1 gene (G2677T) gene polymorphism may be risk factors for acute rejection and this can be attributed to their effect on tacrolimus pharmacokinetics. Tacrolimus therapy may be tailored according to the recipient genotype for better outcome.
Keyphrases
- multidrug resistant
- drug resistant
- gram negative
- liver failure
- acinetobacter baumannii
- klebsiella pneumoniae
- respiratory failure
- copy number
- drug induced
- genome wide
- aortic dissection
- computed tomography
- genome wide identification
- magnetic resonance imaging
- gene expression
- hepatitis b virus
- contrast enhanced
- genome wide analysis
- positron emission tomography
- stem cells
- magnetic resonance
- dual energy
- image quality
- mechanical ventilation
- transcription factor
- replacement therapy
- bone marrow