Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF-β3.
Ilona UzielieneEdvardas BagdonasKazuto HoshiTomoaki SakamotoAtsuhiko HikitaZivile TachtamisevaiteGreta RakauskieneGiedrius KvederasAli MobasheriEiva BernotienePublished in: Stem cell research & therapy (2021)
These data suggest that activin A exerts differential effects on the induction of chondrogenic differentiation in MenSCs vs. BMMSCs, which implies that different mechanisms of chondrogenic regulation are activated in these cells. Following further optimization of differentiation protocols and the choice of growth factors, potentially including activin A, MenSCs may turn out to be a promising population of stem cells for the development of cell-based therapies with the capacity to stimulate cartilage repair and regeneration in OA and related osteoarticular disorders.
Keyphrases
- stem cells
- mesenchymal stem cells
- cell therapy
- induced apoptosis
- endothelial cells
- single cell
- cell cycle arrest
- electronic health record
- transforming growth factor
- induced pluripotent stem cells
- big data
- bone marrow
- sensitive detection
- knee osteoarthritis
- oxidative stress
- cell proliferation
- deep learning
- artificial intelligence
- single molecule