Obesity accelerates age defects in B cells, and weight loss improves B cell function.
Daniela FrascaMaria RomeroAlain DiazBonnie B BlombergPublished in: Immunity & ageing : I & A (2023)
Although the results from our small observational study show that obesity-induced dysfunctional B cell responses, similar to those occurring during aging, are ameliorated in some but not all obese individuals after weight loss, the effects of body weight loss on mechanistic pathways are largely missing and deserve further investigation.