Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model.

Andreas BaranowskiLudwig SchlemmerKatharina FörsterEkaterina SlotinaTim MickanSebastian TruffelAnja KleinStefan G MattyasovszkyAlexander HofmannUlrike RitzPol M Rommens

Published in: Drug design, development and therapy (2019)

Both atorvastatin and losartan reduced the number of myofibroblasts in the posterior knee joint capsule of rat knees 2 weeks after trauma and losartan increased the length of the inferior joint capsule. However, these changes at the cellular level did not translate an increase in range of motion of the rats´ knee joints during early contracture development.

Keyphrases

angiotensin ii
total knee arthroplasty
oxidative stress
knee osteoarthritis
mass spectrometry
high speed
high resolution