C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project.
Natalie ArnoldChristopher M BlaumAlina GoßlingFabian J BrunnerBenjamin BayMarco M FerrarioPaolo BrambillaGiampiero MazzagliaValerio LeoniLuigi PalmieriChiara DonfrancescoTeresa PadróJonas AnderssonPekka JousilahtiFrancisco M OjedaTanja ZellerAllan LinnebergStefan SöderbergLicia IacovielloFrancesco GianfagnaSusana SansGiovanni VeronesiBarbara ThorandAnnette PetersHugh Tunstall-PedoeFrank KeeVeikko V SalomaaRenate B SchnabelKari KuulasmaaStefan BlankenbergWolfgang KoenigChristoph WaldeyerPublished in: European heart journal (2024)
While among CHD-free individuals Lp(a) was significantly associated with incident CHD regardless of hsCRP, in participants with CHD at baseline, Lp(a) was related to recurrent CHD events only in those with residual inflammatory risk. These findings might guide adequate selection of high-risk patients for forthcoming Lp(a)-targeting compounds.