Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
Nicholas JexJohn Pierre GreenwoodRichard M CubbonOliver J RiderAmrit ChowdharySharmaine ThirunavukarasuSindhoora KothaMarilena GiannoudiAnna McGraneAmanda MaccannellMarcella Conning-RowlandSam StrawHenry ProcterSotiris PapaspyrosBetsy EvansKalyana JavangulaAntonella FerraraWalid ElmahdyPankaj KaulHui XuePeter P SwobodaPeter KellmanLadislav ValkovičLee RobertsDavid BeechMark T KearneySven PleinMarc Richard DweckTheodoros D KaramitsosPublished in: Circulation (2023)
Among patients with severe AS, those with T2D demonstrate persistent abnormalities in myocardial PCr/ATP, vasodilator stress MBF, and cardiac contractile function after AVR; AVR effectively normalizes myocardial PCr/ATP, vasodilator stress MBF, and cardiac contractile function in patients without T2D.
Keyphrases
- aortic stenosis
- left ventricular
- aortic valve replacement
- blood flow
- transcatheter aortic valve implantation
- skeletal muscle
- type diabetes
- transcatheter aortic valve replacement
- aortic valve
- heart failure
- smooth muscle
- ejection fraction
- early onset
- drug induced
- coronary artery disease
- glycemic control
- metabolic syndrome