GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1.

Sarah M GrayAndrew L HoseltonRadha KrishnaCris A SlentzDavid A D'Alessio

Published in: The Journal of clinical endocrinology and metabolism (2022)

GLP-1r activation contributes to β-cell secretion in diabetic and nondiabetic people during α-cell activation, but in the absence of increased circulating GLP-1. These results are compatible with regulation of β-cells by paracrine signals from α-cells. This process may be affected by DPP4 inhibition.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
cell therapy
type diabetes
endoplasmic reticulum stress
oxidative stress
cell death
cell proliferation
mesenchymal stem cells
pi k akt
binding protein