Low fetal fraction in obese women at first trimester cell-free DNA based prenatal screening is not accompanied by differences in total cell-free DNA.
Raj ShreeTeodora R KolarovaHayley J MacKinnonJaclynne M HedgeElena VinopalKimberly K MaChristina M LockwoodSuchitra ChandrasekaranPublished in: Prenatal diagnosis (2021)
First trimester obese women have persistently low FF and higher indeterminate rates, without differences in total cfDNA, suggesting placental-specific mechanisms versus dilution from maternal sources as a potential etiology.
Keyphrases
- pregnancy outcomes
- polycystic ovary syndrome
- adipose tissue
- weight loss
- metabolic syndrome
- pregnant women
- type diabetes
- obese patients
- cervical cancer screening
- breast cancer risk
- drinking water
- insulin resistance
- bariatric surgery
- liquid chromatography tandem mass spectrometry
- birth weight
- body mass index
- risk assessment
- ms ms
- fine needle aspiration
- ultrasound guided