Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial.
Christopher K RaynerLinda E WatsonLiza K PhillipsKylie LangeMichelle J BoundJacqueline GrivellChinmay S MaratheKaren Louise JonesMichael HorowitzEleuterio FerranniniDomenico TricòSilvia FrascerraAndrea MariAndrea NataliPublished in: Diabetes care (2020)
Eight weeks' treatment with lixisenatide is associated with sustained slowing of gastric emptying and marked reductions in postprandial glycemia and appearance of ingested glucose. Short-acting GLP-1 receptor agonists therefore potentially represent an effective long-term therapy for specifically targeting postprandial glucose excursions.