Sex differences in the epigenetic regulation of chronic visceral pain following unpredictable early life stress.

Tijs Louwies Beverley Greenwood-Van Meerveld

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

Dysregulated histone acetylation and GR binding at the CRH promoter in the CeA are an important mechanism for "memorizing" ELS events mediating visceral pain in adulthood.

Keyphrases

early life
chronic pain
pain management
dna methylation
neuropathic pain
insulin resistance
stress induced
gene expression
depressive symptoms
transcription factor
spinal cord injury
histone deacetylase
binding protein
postoperative pain