LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration.

Junjun LuanJingqi FuChengjie ChenCongcong JiaoWeiwei KongYixiao ZhangQing ChangYanqiu WangDetian LiGabor G IlleiJeffrey B KoppJingbo PiHua Zhou

Published in: Arthritis research & therapy (2019)

LNA-anti-miR-150 may be a promising novel therapeutic agent for LN in addition to the current emerging monoclonal antibodies, and its renal protective mechanism may be mediated by anti-fibrosis and anti-inflammation as well as reduction of the infiltrated kidney resident macrophages.

Keyphrases

cell proliferation
long non coding rna
oxidative stress
long noncoding rna
adipose tissue
signaling pathway