Monitoring of Cardiac Remodeling in a Mouse Model of Pressure-Overload Left Ventricular Hypertrophy with [18F]FDG MicroPET.
Andrei TodicaNick L BeetzLisa GüntherMathias J ZacherlUlrich GrabmaierBruno HuberPeter BartensteinStefan BrunnerSebastian LehnerPublished in: Molecular imaging and biology (2019)
[18F]FDG-PET is applicable for serial in vivo monitoring of the TAC mouse model. Myocardial hypertrophy, the dilation of the left ventricle, and the decrease in LVEF could be reliably quantified over time, as well as the developing localized scar. The increase in volume over time is predictive of a high fibrosis load.
Keyphrases
- mouse model
- left ventricular
- pet ct
- pet imaging
- positron emission tomography
- mitral valve
- hypertrophic cardiomyopathy
- heart failure
- computed tomography
- cardiac resynchronization therapy
- acute myocardial infarction
- aortic stenosis
- left atrial
- pulmonary hypertension
- acute coronary syndrome
- coronary artery disease
- atrial fibrillation
- congenital heart disease
- pulmonary arterial hypertension
- wound healing
- transcatheter aortic valve replacement