Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease.

Yiqing GuoJesse PaceZhengzhe LiAvi Ma'ayanZichen WangMonica P ReveloEdward ChenXiangchen GuAhmed AttalahYaqi YangChelsea EstradaVincent W YangJohn C HeSandeep K Mallipattu

Published in: Journal of the American Society of Nephrology : JASN (2018)

Inducing podocyte-specific KLF15 attenuates kidney injury by directly and indirectly upregulating genes critical for podocyte differentiation, suggesting that KLF15 induction might be a potential strategy for treating proteinuric kidney disease.

Keyphrases

diabetic nephropathy
high glucose
transcription factor
genome wide
risk assessment
dna methylation
human health
climate change
bioinformatics analysis
genome wide analysis