Gender differences in clinical and biochemical parameters among patients hospitalized for schizophrenia: towards precision medicine.
Cecilia Maria EspositoFrancesca De CagnaAlice CaldiroliEnrico CapuzziAlessandro CeresaMartina Di PaoloAnna Maria AuxiliaMartina CapellazziIlaria TagliabueLuisa CirellaMassimo ClericiNatascia BrondinoJennifer L BarkinPierluigi PolitiMassimiliano BuoliPublished in: European archives of psychiatry and clinical neuroscience (2023)
Our analyses indicate a less severe clinical profile in female patients. This is evident especially in the early years of the disorder, as suggested by less comorbidity with psychiatric disorders or later age at onset; this is consistent with the related literature. In contrast, female patients seem to be more vulnerable to metabolic alterations as demonstrated by more frequent hypercholesterolemia and thyroid dysfunction. Further studies are needed to confirm these results in the framework of precision medicine.