Hypoxia-Responsive Polymeric Nanoprodrugs for Combo Photodynamic and Chemotherapy.
Dan ZhaoYixin ZhangZiming YanYue DingFengming LiangPublished in: ACS omega (2023)
Hypoxia in most solid tumors is a major challenge for photodynamic therapy (PDT), and the combination of hypoxia-activated chemotherapy and PDT is a promising approach for enhanced anticancer activity. Herein, we designed hypoxia-responsive polymeric nanoprodrug PNPs to co-deliver photosensitizer 5,10,5,20-tetrakis(4-aminophenyl)-porphine (TAPP) and chlorambucil (CB) to improve the overall therapeutic efficacy. Upon laser irradiation, the central TAPP converted oxygen to produce single oxygen ( 1 O 2 ) for PDT and induced PDT-reduced hypoxia environment, which accelerated the release of activated CB for synergetic cancer cell killing. Consequently, these hypoxia-responsive polymeric nanoprodrugs with a considerable drug-loading content and synergistic therapeutic effect of PDT-CT had great potential for tumor therapy.
Keyphrases
- photodynamic therapy
- cancer therapy
- endothelial cells
- drug delivery
- fluorescence imaging
- high glucose
- magnetic resonance imaging
- computed tomography
- stem cells
- drug release
- radiation therapy
- magnetic resonance
- locally advanced
- drug induced
- mesenchymal stem cells
- high resolution
- contrast enhanced
- adverse drug
- high speed