Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Hope S Rugo Kira Raskina Alexa B Schrock Russell W Madison Ryon P Graf Ethan S Sokol Smruthy S Sivakumar Jessica K Lee Virginia A Fisher Geoffrey R Oxnard Hanna Tukachinsky

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

CGP detects diverse PIK3CAm in a greater number of patients with ABC than PCR hotspot testing; 20% of patients with PIK3CAm do not have SOLAR1m. These patients may derive benefit from alpelisib.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors