Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs.
Clara Salles FigueiredoElias Soares RoseiraTainá Teixeira VianaMarcelo Augusto Duarte SilveiraRodrigo Morel Vieira de MeloMiguel Godeiro FernandezLivia Maria Goes LemosLuiz Carlos Santana PassosPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Atherosclerosis is a lipid-driven immune-inflammatory disease that affects the arteries, leading to multifocal plaque development. The inflammatory process involves the activation of immune cells and various inflammatory pathways. Anti-inflammatory drugs have been shown to be effective in reducing cardiovascular events in individuals with coronary disease. However, their use is still limited due to concerns about long-term follow-up, cost-effectiveness, adverse effects, and the identification of the ideal patient profile to obtain maximum benefits. This review aims to improve the understanding of inflammation in coronary atherosclerosis and explore potential therapeutic interventions, encompassing both traditional and non-traditional anti-inflammatory approaches. By addressing these concepts, we seek to contribute to the advancement of knowledge about this type of treatment for coronary artery disease.
Keyphrases
- coronary artery disease
- cardiovascular events
- anti inflammatory drugs
- oxidative stress
- percutaneous coronary intervention
- cardiovascular disease
- coronary artery bypass grafting
- anti inflammatory
- coronary artery
- healthcare
- physical activity
- case report
- heart failure
- left ventricular
- type diabetes
- blood flow
- atrial fibrillation
- aortic valve
- transcatheter aortic valve replacement
- ejection fraction