Can Scoliotic Discs Be Controls for Molecular Studies in Intervertebral Disc Research? Insights From Proteomics.
Dr Shanmuganathan RajasekaranChitraa TangavelK S Sri Vijay AnandDilip Chand Raja SoundararajanSharon Miracle NayagamR SunmathiM RaveendranAjoy Prasad ShettyRishi Mugesh KannaPushpa Bhari ThippesamyPublished in: Global spine journal (2020)
Findings of our study confirm that scoliotic discs have an abundance of inflammatory, oxidative stress response proteins, which are either absent or downregulated in the ND group indicating that scoliotic discs are not pathologically inert. Furthermore, this study has established MRI-normal discs from voluntary organ donors as the "true" control for molecular studies in IVD research.