Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.

Ding-Qi Lu Xin-Yi YaoYa-Ting RenKai-Yuan ZhangXin-Chao ZhuTao HongXue YuZhi-Min XieLi-Ying ChenXin-Chang Wang

Published in: International journal of rheumatic diseases (2023)

Clinical sample validation suggested that HLA class I, ADAR, and OAS2 might play a role in the development of SS. Our study shows epigenetic regulatory mechanisms and potential disease markers associated with SS, which in turn will enable us to identify new therapeutic targets.

Keyphrases

dna methylation
genome wide
gene expression
copy number
transcription factor
single cell
fluorescent probe
human health
rheumatoid arthritis
quantum dots
risk assessment