Associations between male infertility and ancestry in South Americans: a case control study.
Maria Fernanda SkowronekTatiana VelazquezPatricia MutGonzalo FigueiroMonica SansBernardo BertoniRosanna SapiroPublished in: BMC medical genetics (2017)
The data presented in this study showed an association between male infertility and ancestry in the
Uruguayan population. Specifically, abnormal sperm morphology was associated with the Y chromosome haplogroup F(xK). Since the Y chromosome lacks recombination, these data suggest that some genes that determine sperm morphology might be inherited in blocks with the region that determines specific haplogroups. However, the possible association between the Y chromosome haplogroup F(xK) and sperm morphology requires further confirmatory testing. Data linking infertility with ancestry are needed to establish the possible causes of infertility and define male populations susceptible to infertility. Whether the admixed characteristics of the Uruguayan population exert any pressure on male fertility potential must be further investigated.
Keyphrases
- mitochondrial dna
- polycystic ovary syndrome
- copy number
- electronic health record
- big data
- genome wide association study
- type diabetes
- dna damage
- genome wide
- oxidative stress
- gene expression
- skeletal muscle
- data analysis
- high resolution
- adipose tissue
- dna repair
- mass spectrometry
- risk assessment
- atomic force microscopy
- genetic diversity